منابع مشابه
Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance.
BACKGROUND Obesity is associated with an increased risk of developing microangiopathy, hypertension, and insulin resistance. We hypothesized that obesity is a primary cause of microvascular dysfunction, which may contribute to the development of these obesity-related disorders. METHODS AND RESULTS We examined microvascular function in 16 lean (body mass index <24 kg/m2) and 12 obese (body mas...
متن کاملObesity and Cardiac Microvascular Function
Introduction: Roux-en-Y gastric bypass (RYGB) reduces weight and long-term cardiovascular risk in obese patients. We showed that endothelial-mediated vasorelaxation improves rapidly in diet-induced obese (DIO) rats within 8 days after RYGB and is associated with reduced activation of JNK independently from weight loss. Purpose: We investigated whether in vivo inhibition of JNK with two differen...
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We read with interest the findings of Sasso et al. regarding the effects of insulin on left ventricular function during exercise in obese subjects. The authors conclude that their results ‘suggest a metabolic pathogenesis for the impaired left ventricular function in obesity’. This may be true, but the data they divulge do not support this conclusion. Most importantly, their interpretation that...
متن کاملImpaired Microvascular Reperfusion
1. Morgan H, White RP, Pennick M, Robertson JT: Prostaglandins and experimental cerebral vasospasm. Surg Forum 23: 447-448, 1972 2. Wilson JL, Feild JR: The production of intracranial vascular spasm by hypothalamic extract. J Neurosurg 40: 473-479, 1974 3. Allen GS, Gold LHA, Chou SN, et al: Cerebral arterial spasm. Part 3: In vivo intracisternal production of spasm by serotonin and blood and i...
متن کاملImpaired atrial M(2)-cholinoceptor function in obesity-related hypertension.
The aim of this study was to investigate the activity of the parasympathetic limb of the baroreflex arch in a canine model of obesity-related hypertension. Twelve male beagle dogs were randomized into 2 groups. Six dogs were fed with normal canine food and 6 were submitted to a 10-week high-fat diet (HFD). We have evaluated the consequences of HFD on heart rate (HR) and blood pressure (BP) circ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2004
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000129772.26647.6f